The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function
Manoj Doss
Summary
This study will test the effects of psilocybin on memory and cognition in healthy participants using computerized tasks and magnetic resonance imaging (MRI).
Description
In a double-blind, placebo-controlled, repeated measures design in healthy participants, this study will test the effects of psilocybin on memory and cognition in healthy individuals using computerized tasks and magnetic resonance imaging (MRI). A better understanding of the basic neurocognitive effects of psilocybin may allow for minimizing potential harms and maximizing potential benefits of psilocybin therapy.
Eligibility
- Age range
- 21–45 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * 21 to 45-years-old. * 3-30 lifetime psychedelic uses. * English as a first language. * High school education (or equivalent) * Psychiatrically healthy (as assessed by the SCID-5). * Medically healthy (as assessed by a physical examination and ECG). * Willingness to attend all study sessions and complete all procedures. * BMI between 19 and 30. Exclusion Criteria: * Current or past diagnosis of psychiatric disorders except panic attacks, depressive disorder, or anxiety, or disorder from ≥1 year prior. * Current or past medical conditions that might interfere with study…
Interventions
- DrugPlacebo
This is an inactive control condition.
- DrugPsilocybin 15mg
This is a moderate psychoactive dose.
Location
- The University of Texas at Austin Dell Medical SchoolAustin, Texas