Developing EEG Biomarkers for OUD Diagnostic, Prognostic, and Predictive Purposes
University of Illinois at Chicago
Summary
The US is suffering from a national opioid epidemic characterized by significant costs, overdoses, and deaths. Conventional Opioid Use Disorder (OUD) treatments (i.e., pharmacological and psychosocial interventions) are characterized by limited or diminishing efficacy, ceiling effects, and/or serious side effects. The availability of validated OUD biomarkers would be a key step in the development and approval of better treatments. Ultimately, the scarcity of OUD biomarkers represents a significant unmet need in the fight against opioid addiction as recognized by NIDA and the FDA with their support for development of Medical Device Development Tools (MDDT) and biomarker tests for OUD. Advances in neuroimaging techniques, and in particular recent evidence supports electroencephalography (EEG) as a promising candidate to investigate the correlation between addiction and brain state. To address the clear medical and market need for OUD biomarkers, this is a feasibility study to identify and assess potential EEG biomarkers for OUD diagnoses, disease monitoring, and prediction of OUD treatment response.
Description
We will recruit up to 130 subjects for this study, with the intention of enrolling 50 OUD subjects at various stages of treatment and 20 age-matched non-OUD controls. Eligible subjects will contact or give verbal permission to be contacted via their referring provider, by a co-investigator to obtain more information about the study. At the first point of contact (usually a phone call), study co- investigator will administer a phone-screening questionnaire. Once the phone screening process is complete, the information gathered by the co-investigator will be taken to the PI of the study for fur…
Eligibility
- Age range
- 22–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * For OUD Subjects: 1. Providing informed consent to participate in the study. 2. 22 to 85 years old. Having a diagnosis of OUD • OUD of more than 6 months duration as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM-5) \[71\] with a positive urine toxicology screen who still feel craving. 4\. Lives in immediate area with no plans to relocate. For age-matched controls: 1. Providing informed consent to participate in the study. 2. 22 to 85 years old. 3. Lives in immediate area with no plans to relocate Exclusion Criteria: * For OUD Subjects:…
Location
- Clinical & Imaging Research Outcomes LabChicago, Illinois