The Impact of Live Attenuated Intranasal Influenza Vaccine Exposure on Mucosal Immunity
University of Maryland, Baltimore
Summary
The research of the investigators is focused on the understanding how the immune system functions and responds to intranasal vaccines. Intranasal vaccines do not lead to the same changes in the blood that intramuscular vaccines do. Therefore, the investigators want to look at the function of immune (lymphoid) organs that are near the nose. The closest immune organs are the adenoids and tonsils. Mice do not have tonsils allowing for the investigators to answer these questions. Human lymphoid tissue will allow the investigators to better understand the molecular behavior of these cells in humans. The purpose of this protocol is to administer the FDA approved live attenuated influenza vaccine or no vaccine to patients undergoing adenoidectomy and/or tonsillectomy for obstructive sleep apnea prior to surgery and then collect the tissue (adenoid and/or tonsil tissue) that would normally be discarded from surgery. This will allow for improved understanding of what happens after vaccination.
Eligibility
- Age range
- 2–89 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Patient undergoing tonsillectomy and adenoidectomy as part of the standard of care for sleep apnea Exclusion Criteria: * Chronic Tonsillitis * Immune Deficiency * Already received this year's flu vaccine
Interventions
- BiologicalLive Attenuated Influenza Vaccine
Nasal spray
Location
- University of Maryland Medical CenterBaltimore, Maryland