Autonomic Neural Blockade During Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial Evaluating Pain and Nausea After Bariatric Surgery
Endeavor Health
Summary
The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain/nausea during the first 72 hours after sleeve gastrectomy or gastric bypass surgery. Participants will be randomly assigned either to the standard of care or the ANB group before surgery. As part of standard of care, in both groups, laparoscopic bariatric surgery will be initiated with local anesthetic injected into the abdominal wall. In the ANB group, participants will be given an additional injection of local anesthetic medication to block nerves on and around the stomach.
Description
Gastric bypass and sleeve gastrectomy are the most common and successful weight loss surgeries. The advancement of laparoscopic, minimally invasive techniques allows these procedures to be performed with low morbidity and a relatively easy recovery, when broadly considering abdominal surgery. The major complaints postoperatively are abdominal pain and nausea, which can require medications to control and may prolong hospital stay. There is evidence autonomic neural blockade (ANB) improves pain and nausea in the immediate postoperative period. ANB has been shown to be therapeutic in the surgical…
Eligibility
- Age range
- 18–90 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Individuals able and willing to consent and participate in all study activities * Adults, ages 18-90 * All patients with severe obesity undergoing laparoscopic/robotic gastric bypass or sleeve gastrectomy Exclusion Criteria: * Patients taking opiates chronically * Patients allergic to study medications * Patients with any prior adverse reaction to ingredients included in the block * Adults unable to consent * Pregnant women * Prisoners
Interventions
- ProcedureIntraoperative autonomic neural blockade (ANB)
Local anesthetic block of the neurovascular tissue along the lesser curve of the stomach and celiac trunk during sleeve gastrectomy or gastric bypass surgery.
- ProcedureLaparoscopic Standard of Care Abdominal Wall Block
Administration of local anesthetic to abdominal incisions (standard of care)
Location
- Endeavor HealthEvanston, Illinois