Vision Improvement Through Behavioral Rehabilitation And Neuroplasticity Training
Georgetown University
Summary
The VIBRANT (Vision Improvement through Behavioral Rehabilitation And Neuroplasticity Training) study is a prospective, double-blind, crossover design (within-subject) in participants with homonymous hemianopia-a type of visual field loss resulting from damage to the post-chiasmatic visual pathways. It aims to investigate whether transcranial random noise stimulation (tRNS) combined with perceptual learning-based training has potential for improving visual impairments.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
A. Stroke, brain tumor, or traumatic brain injury patients Inclusion Criteria: 1. At least 18 years of age. 2. Capable of providing informed consent and complying with study procedures. 3. Unilateral or bilateral focal brain damage causing loss of vision. 4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year. Exclusion Criteria: 1. Severe CNS diseases or disorders unrelated to the focal lesion, which could interfere with study results. 2. Severe mental health challenges that could interfere with study results, or current or recent (wit…
Interventions
- Devicetranscranial random noise stimulation (tRNS)
Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: 1 mA current intensity, with a frequency range of 101-640 Hz.
- DeviceSham Stimulation
Stimulation location: bilateral human middle temporal complex (hMT+). Stimulation parameters: Ramp up stimulation at 1mA with a frequency range of 101-640Hz for the first 30 seconds followed by no current for the remainder of the duration.
- BehavioralPerceptual learning-based training
A motion discrimination task, judging the global direction of moving dot stimuli with two different coherence levels.
Location
- Georgetown University Medical CenterWashington D.C., District of Columbia