Examining the Role of Cooling Agents in Oral Nicotine Pouches

Summary

This clinical trial studies how the flavors and synthetic coolant properties in oral nicotine pouches (ONPs) compare to one another and how these characteristics are perceived by users. ONPs are placed between the gum and lip, and the nicotine is absorbed in the mouth. They have a strong potential for harm reduction if smokers can switch to using them, and they are growing in popularity. One factor that could be contributing to the increase in popularity is the wide range of flavors, including mint or menthol. With recent flavor restriction policies that have gone into effect in certain areas of the United States, ONPs are now including synthetic cooling agents (WS-3) in place of the flavors. They provide a cooling sensation, but do not have a characterizing flavor, like mint or menthol, allowing them to be sold where flavor restriction policies are in place. Learning more about the flavors and cooling properties in ONPs and user preferences may help researchers guide future ONP regulation and understand how these characteristics may be used as a potential harm reduction or quit smoking tool.

Description

Eligibility

Age range

21+ years

Sex

All

Healthy volunteers

Yes

Interventions

• Procedure
  Carbon Monoxide Measurement

  Ancillary studies

• Drug
  Nicotine Oral Pouch

  Sample randomly-ordered ONPs

• Other
  Questionnaire Administration

  Ancillary studies

• Drug
  Smoke usual brand cigarette

  Participant will smoke their usual brand of cigarette during 1 study visit for 5 minutes.

Location