Fatty Acid Binding Proteins and Markers of Cellular Senescence in Cancer Survivors
Case Comprehensive Cancer Center
Summary
The purpose of this research study is to investigate whether cancer survivors have higher levels of proteins called Fatty Acid Binding Proteins as well as 12 different markers of cellular senescence than people who have never had cancer. Investigators believe that these levels may be elevated in cancer survivors as a result of their cancer and the treatments they received and may put them at higher risk for chronic conditions such as high cholesterol, diabetes, high blood pressure, and obesity. This study will also compare the levels of these proteins and inflammatory markers in the blood with different aspects of cancer treatment the survivors received. Investigators are investigating if there is a correlation between levels of these proteins and markers, the type of treatment cancer survivors received, and development of metabolic conditions.
Description
Recent advances in cancer-directed therapies for pediatric patients has led to increasing numbers of survivors of childhood and young adult cancers who face unique long term health risks as a result of their cancer and the exposure to tissue damaging agents, including chemotherapy, radiation therapy and immune modulating agents. Risks associated are often dependent on the type of cancer, age at diagnosis, and treatment received with many agent-specific potential late effects . However, previous studies of childhood and young adult cancer survivors have shown that they are at significantly incr…
Eligibility
- Age range
- 5–50 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosis of at least one malignancy for which chemotherapy, radiation, and/or stem cell transplantation was utilized as part of treatment * Completed all therapeutic interventions for their malignancy and are at least 2 years off therapy * At least 1-year post-stem cell transplant for malignant condition Exclusion Criteria: 1. Pregnancy at the time of the study 2. Any autoimmune condition including but not limited to lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis, type 1 diabetes, EXCEPT well-controlled autoimmune hypothyroidism for at least 6 months…
Interventions
- OtherSpecimen #1
Specimen 1 will be collected in a 10 ml SST (serum separator tube).
- OtherSpecimen #2
Specimen #2 will be collected in a 10 ml SST (serum separator tube)
Location
- Case Comprehensive Cancer Center, UH Rainbow Babies & Children's HospitalCleveland, Ohio