Brown University
This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.
There are three aims in this study that test the hypothesis that probenecid compared to placebo, decreases: * Aim 1 (laboratory phase): acute alcohol craving. * Aim 2 (naturalistic phase): alcohol craving. * Aim 3 (naturalistic phase): alcohol consumption
Inclusion Criteria: * • Male or female, ≥18 years. * women \>7 drinks/week; men \>14 drinks/week. * meet moderate to severe AUD score for DSM-5 criteria. * Breath Alcohol Content (BrAC)=0.00 at each visit. * in good health as confirmed by medical history, physical examination and lab tests. * willing to adhere to the study procedures. * understand informed consent and questionnaires in English at an 8th grade level. Exclusion Criteria: * • Women who are breastfeeding or positive urine test for pregnancy. * clinically significant medical abnormalities: unstable hypertension,…
2gr daily
Inactive compound
Arctuva estimate
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