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Evaluating a Mechanistically-Supported Pharmacotherapy to Treat Opioid Withdrawal
The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of busp…
A Theory-Informed Examination of a Brief Visuospatial Intervention and Its Mechanisms for Reducing Alcohol Cravings and Consumption
The goal of this clinical trial is to examine whether dynamic visual noise (DVN), a short video array of rapidly moving black and white squares, reduces cravin…
Probenecid, Pannexin 1 Channels for Alcohol Use Disorder
This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals wi…
Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder
The proposed clinical trial would evaluate the use of smartphone applications ("apps", which have well-established efficacy in reducing cigarette and alcohol u…
Developing a Clinical Outcome Assessment for Opioid Craving
The purpose of this study is to collect information about opioid craving so that the investigators can develop an opioid craving assessment to improve treatmen…
Assessing a Clinically-meaningful Opioid Withdrawal Phenotype
Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicat…
Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder
The proposed project will include enrollment of 200 daily tobacco cigarette users, ages 22+, from the San Diego community. Participants will be assessed on the…
Cognitive and Affective Mechanisms Underlying an Olfactory Approach to Modify Cigarette Craving: A Neurobehavioral Investigation
The proposed study uses fMRI and behavioral measures in and outside the laboratory to investigate the neurobehavioral mechanisms underlying the impact of pleas…
State-Dependent Interoception, Value-Based Decision Making, and Introspection
Background: Negative emotional states can affect a person s behavior as they make decisions. For example, hunger may make people more impatient; they may then…
Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving
Cannabidiol (CBD), one of the most prevalent cannabinoids in cannabis (marijuana) has been shown to reduce alcohol withdrawal symptoms in laboratory animals. I…