Oral Losartan to Decrease the Risk of Postoperative Arthrofibrosis Following Primary and Revision Anterior Cruciate Ligament Reconstruction
Rush University Medical Center
Summary
The purpose of this study to investigate the effect of using losartan (a blood pressure lowering drug with anti-scarring properties) on preventing primary postoperative arthrofibrosis (formation of abnormal scar tissue) in the knees in participants undergoing anterior cruciate ligament (ACL) repair surgery of their knee.
Description
Losartan, an angiotensin-II receptor blocker (ARB), approved by the Food and Drug Administration (FDA) for the treatment of hypertension and diabetic nephropathy, has garnered recent interest in the field of orthopedic surgery as an anti-fibrotic (anti-scarring) agent. Losartan's primary mechanism of action as an anti-hypertensive involves acting as a receptor antagonist for angiotensin II, a peptide produced by the liver which causes vasoconstriction, release of anti-diuretic hormone from the pituitary gland, and release of aldosterone from the adrenal glands, among other functions. Losartan…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Must be undergoing a primary ACLR with or without the following: * Chondroplasty * Synovectomy * Loose body removal * Removal of hardware * Meniscal surgery (excluding meniscal allograft transplantation/MAT) * Lateral extra-articular tenodesis * Must have skeletal maturity in the distal femur and proximal tibial physes * Must be age 18 years or older at time of enrollment Exclusion Criteria: * \<18 years at time of enrollment * No diagnosis of ACL tear * ACL repairs * Revision ACL reconstructions * Open distal femur or proximal tibia physes * Major concomitant procedur…
Interventions
- DrugLosartan
Two types of losartan capsules will be compounded by combining a broken-up 25mg or 50mg losartan tablet and microcrystalline cellulose placebo filler to eliminate rattling of the broken tablet inside of the capsule. The 25mg losartan capsules will be yellow and the 50 mg losartan capsules will be blue.
- OtherPlacebo
The placebo capsules will consist of microcrystal cellulose and will come in yellow and blue to appear identical to the losartan capsules.
Location
- Rush University Medical CenterChicago, Illinois