MC240903 Ex Vivo Expansion of Tumor Antigen-Specific T Cells for Adoptive T Cell Therapy
Mayo Clinic
Summary
The purpose of this study is to understand how the body's immune cells respond to a new type of vaccine (neoantigen vaccine) designed to help the immune system recognize and fight cancer. To do this, the study team will collect a research specimen from participants to study their immune cells' reactions to the neoantigen vaccine. This research will help researchers learn more about how these vaccines might work to protect or treat against cancer.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Histologically confirmed current or previous solid malignancy or healthy individuals * Willing to provide mandatory research blood draw or apheresis per protocol * Provide written informed consent * The following laboratory values obtained ≤ 28 days prior to registration * Hemoglobin ≥10.0 g/dl * Absolute neutrophil count (ANC) ≥1500/mm\^3 * Platelet count ≥100,000/mm\^3 Exclusion Criteria: * Any of the following prior therapies: * IV antibiotic ≤2 weeks prior to apheresis * Major Surgery ≤4 weeks prior to registration * Received a live vaccine ≤30 days p…
Interventions
- ProcedureBlood Draw
Participants have a standard blood draw or apheresis on study. Some participants may provide a specimen via apheresis one time (the "blood draw group") and then elect to provide a second optional specimen via a standard blood draw (the "apheresis draw group") or vice versa.
- ProcedureApheresis
Participants have a standard blood draw or apheresis on study. Apheresis is a procedure where blood is drawn from your body, specific components like plasma, platelets, and/or white blood cells are separated out, and the rest of the blood is returned. Some participants may provide a specimen via apheresis one time (the "apheresis group") and then elect to provide a second optional specimen via a standard blood draw (the "blood draw group") or vice versa.
Location
- Mayo Clinic in FloridaJacksonville, Florida