Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder
University of Minnesota
Summary
The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals under buprenorphine maintenance treatment for OUD (bOUD).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * ability to provide consent and comply with study procedures * Diagnostic and Statistical Manual of Mental Disorders criteria for OUD * undergoing buprenorphine maintenance treatment. Participants may have current comorbid drug use, but primary diagnosis must be OUD * Intention to remain in the addiction treatment program until intervention completion. Exclusion Criteria: * Any medical condition with neurological sequelae * head injury resulting in skull fracture or loss of consciousness of \>30 minutes * any tDCS or MRI contraindication (tDCS: history of seizures, meta…
Interventions
- DeviceTranscranial Direct Current Stimulation (tDCS)
We will deliver 2-mA tDCS current intensity during a 30 minute stimulation period (including a 30-second ramp-up and 30-second ramp-down period) to the dorsolateral prefrontal cortex. Electrodes will be fixed on marked locations based on the 10-20 EEG system. Anodal stimulating electrode will be over the left DLPFC (F3) and cathodal electrode over the right DLPFC (F4).
- DeviceSham Stimulation
electrodes will have the same montage as active tDCS (F3/F4), but current will be ramped down after the initial 30 seconds ramp-up period. Thus, participants will feel the initial sensation associated with tDCS but will receive no active current for the rest of the stimulation period.
Location
- University of MinnesotaMinneapolis, Minnesota