Reducing Neural Perseveration Through Closed Loop Real Time fMRI Neurofeedback to Alleviate Depressive Symptoms
University of Pennsylvania
Summary
This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD. This real-time fMRI neurofeedback therapy uses cloud-based pattern classification to decode a patient's attentional state and dynamically modulate task stimuli (in a closed loop) based on this state.
Description
The investigators will compare cloud based real time fMRI feedback with placebo (sham feedback) in reducing negative attention bias and depressive symptoms. This study will be the first dose-finding test of real-time fMRI effect on negative attention bias. Measures include: Structured Clinical Interview for DSM-5 (SCID), Clinician-administered diagnostic exam, Montgomery Asberg Depression Rating Scale (MADRS), Clinician-administered scale used to assess the severity of depression, State-Trait Anxiety Inventory (STAI), Self-report questionnaire used to measure types of anxiety and mood symptoms…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Gender, inclusive * Adult aged 18 - 65 * Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD according to the Clinician-Administered MDD Scale for DSM-5 (unipolar depression or bipolar II depressed) * Scores at least a minimum score of 16 on Montgomery Asberg Depression Rating Scale (MADRS) * Normal cognition * Participants must be able to read and understand English * Participants must be able to provide consent Exclusion Criteria: * Pregnancy (female participants) * Outside age range * MRI contraindications (medical implant, claustrop…
Interventions
- BehavioralActive Closed Loop Real Time fMRI Neurofeedback
Active neurofeedback to target neural mechanisms underlying attentional bias in participants with major depressive discover (MDD)
- BehavioralSham Closed Loop Real Time fMRI Neurofeedback
Sham (placebo) neurofeedback to target neural mechanisms underlying attentional bias in participants with major depressive discover (MDD)
Location
- Center for Neuromodulation in Depression and StressPhiladelphia, Pennsylvania