Repurposing Tc 99m Tilmanocept Imaging for Cardiac Sarcoidosis
Duke University
Summary
The purpose of this study is to see if Tc 99m Tilmanocept SPECT/CT imaging can be used to identify cardiac sarcoidosis.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Cohort 1: 1. The participant has provided written informed consent with HIPAA (Health Information Portability and Accountability Act) or equivalent authorization before the initiation of any study-related procedures. 2. Women of reproductive potential must have a negative urine pregnancy test at the time of the study. 3. The participant is at least 18 years of age. 4. The participant has a histological diagnosis sarcoidosis and meets 2014 HRS, 2014 WASOG, or 2016 JCS criteria for cardiac sarcoidosis. 5. The participant has had a clinically indicated cardiac PET-CT showing…
Interventions
- DrugTc 99m tilmanocept
150 mcg containing 10 mCi of Tc 99m tilmanocept will be administered through an IV route of injection. SPECT-CT imaging will then be performed.
- DrugTc 99m tilmanocept
150 mcg containing 10 mCi of Tc 99m tilmanocept will be administered through a SC route of injection. SPECT-CT imaging will then be performed.
Location
- Duke University HospitalDurham, North Carolina