Stanford University
The goal of this clinical trial is to learn if focused ultrasound delivered to the brain influences the effects of the anesthetic medication propofol. It will also learn about the safety and feasibility of using ultrasound and anesthesia together to influence the brain. The main questions it aims to answer are: * Does focused ultrasound delivered to the brain influence the effects or the strength of propofol? * Does propofol anesthesia influence the effects of ultrasound delivered to the brain? Researchers will compare focused ultrasound with sham ultrasound (similar technology but not targeted to a brain region) and administer propofol anesthesia, while measuring signals from the brain and behaviors of participants. Participants will: * Obtain one non-contrast MRI scan of the brain * Receive two separate sessions of ultrasound to the brain (one focused and one sham) * Undergo two separate sessions of propofol anesthesia in a laboratory
Inclusion Criteria: 1. Male or female, 18 to 65 years of age, inclusive, at time of screening. 2. Body mass index between 17-35 kg/m2. 3. Able to read, understand, and provide written, dated informed consent prior to screening. Participants will be deemed likely to comply with study protocol and communicate with study personnel about adverse events and other clinically important information. 4. If female, a status of non-childbearing potential or use of an acceptable form of birth control per the following specific criteria: 1. Non-childbearing potential (e.g., physiologically incapable o…
Active (focused) ultrasound
Sham (unfocused) ultrasound
Intravenous propofol administration
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