Genetics of Neonatal Encephalopathy and Related Disorders
Boston Children's Hospital
Summary
Investigators at Boston Children's Hospital are conducting research in order to better understand the genetic factors which may contribute to neonatal encephalopathy (NE) and related disorders. These findings may help explain the broad spectrum of clinical features and outcomes seen in individuals with a history of NE.
Description
Neonatal encephalopathy (NE) is a disorder of term newborns involving dysfunction of the central nervous system and can impact one's health throughout the lifespan. While NE can be caused by a number of exposures or external factors, in some cases there is no cause identified or the severity of the condition cannot fully be explained by external factors. In these cases, there is increasing evidence to suggest underlying genetic factors may contribute to NE. The investigators' research effort is focused on identifying genetic changes (known as "DNA variants") that cause or contribute to NE. By…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- No
Proband Criteria: Inclusion Criteria: * Diagnosed with neonatal encephalopathy during the neonatal period as documented in the electronic medical record * Less than 6 years old at the time of study enrollment * Patient at Boston Children's Hospital Exclusion Criteria: * Genetic cause of NE already identified * Deceased prior to enrollment Parent criteria: Inclusion Criteria: \- Biological parent of eligible proband (see above)
Location
- Boston Children's HospitalBoston, Massachusetts