[18F]-AraG PET Imaging for Enhanced Risk Stratification and Chemoradiotherapy Response Assessment in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma
Indiana University
Summary
This study will use \[18F\]-AraG PET/CT scans to monitor patients who have been diagnosed with locally advanced Head and Neck Squamous Cell carcinoma (LA-HNSCC), and are planning to undergo standard of care chemoradiotherapy for treatment.
Description
Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer globally. Definitive chemoradiotherapy (CRT) remains the standard of care (SOC) treatment for LA-HNSCC, yet some patients are unsuccessfully treated. The purpose of this study is to explore the feasibility and possible function of \[18F\]-AraG PET/CT (a diagnostic procedure that uses a radioactive tracer \[A method that uses radioactive substances to make pictures of areas inside the body\] to image tumors and assess response to treatment) scans performed before and during treatment to monitor response in patients…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria 1. Patients ≥18 years of age. 2. Ability to provide written informed consent and HIPAA authorization. 3. LA-HNSCC in the larynx, hypopharynx, or human papillomavirus (HPV) negative oropharynx and is planning to receive definitive CRT as the SOC treatment, which includes a total of 70 Gy of radiation dose in 33 fractions, delivered over 5 days a week for 7 weeks, as well as planned weekly cycles of cisplatin (CDDP). 4. Tumor stage III and IV (AJCC 8th edition). 5. Unresectable cases. 6. Eastern Cooperative Oncology Group (ECOG) performance status 0-2 7. Willing and able to m…
Interventions
- Drug[18F]-AraG radiotracer
\[18F\]-AraG radiotracer, which occurs on the first and sixteenth day of treatment.
- DrugChemotherapy
Concurrent chemoradiotherapy (CRT) with weekly doses of cisplatin.
- DeviceRadiotherapy
Concurrent chemoradiotherapy (CRT) of 70Gy of radiation dose in 33 fractions.
Location
- Indiana UniversityIndianapolis, Indiana