Sedentary Behavior, Physical Activity, and 24-hour Behavior in Pregnancy and Offspring Health: the Pregnancy 24/7 Offspring Study
Kara Whitaker
Summary
There is growing evidence that maternal health and behaviors in pregnancy, such as pre-pregnancy obesity, excessive gestational weight gain, poor diet, smoking, and adverse pregnancy outcomes, are linked to fetal programming for obesity and cardiovascular disease (CVD) risk in the offspring. Yet, there is a surprising lack of research on the role of prenatal sedentary behavior, physical activity, and sleep (conceptualized together as 24-hour behavior) on offspring obesity risk and CVD risk; this is an unfortunate research gap since there is strong physiological rationale that these behaviors in pregnancy could influence offspring health and are modifiable intervention targets in pregnancy. This multi-site observational cohort study will leverage state-of-the-art, 24-hour behavior assessment in each trimester of pregnancy, collected as part of the Pregnancy 24/7 cohort study and add additional assessments of offspring growth, adiposity, and CVD risk through 24 months to inform future primordial prevention interventions to decrease the risk of offspring obesity and CVD across the lifespan.
Description
Over the past three decades, there has been an alarming increase in the incidence of childhood obesity. Childhood obesity leads to early onset of cardiovascular risk factors, and both obesity and cardiovascular risk factors track into adulthood and contribute to the epidemic of cardiovascular disease (CVD). The Developmental Origins of Health and Disease theory posits that risk for obesity and CVD is, in part, programmed in utero. To prevent this early entrenchment into obesity and CVD, identification of modifiable maternal factors during pregnancy that later impact offspring risk in early chi…
Eligibility
- Age range
- 0–47 years
- Sex
- All
- Healthy volunteers
- Yes
Maternal Inclusion Criteria: * Enrolled in Pregnancy 24/7 Study. * Completed at least one 24-hr behavior assessment, with valid objective activity monitor data and questionnaires. * Pregnancy resulted in singleton live birth. Offspring Exclusion Criteria: -Child diagnosed with congenital or chromosomal abnormalities that may affect growth or CVD risk.
Locations (3)
- University of IowaIowa City, Iowa
- University of PittsburghPittsburgh, Pennsylvania
- West Virginia UniversityMorgantown, West Virginia