Intermittent Hypoxia Training and Cerebrovascular Health in Older Adults With Type 2 Diabetes
Darren P Casey
Summary
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).
Description
Aging is considered a major risk factor for the development of various cardio- and cerebrovascular related diseases, with vascular endothelial dysfunction representing one of the earliest vascular complications. Age-related cerebrovascular endothelial dysfunction contributes to a progressive decrease in cerebral blood flow, which is associated with lower measures of cognitive function, including information-processing speed, executive function, and global cognition in older adults. Similar to aging, type 2 diabetes mellitus (T2DM) also negatively impacts vascular endothelial function. There is…
Eligibility
- Age range
- 60–85 years
- Sex
- All
- Healthy volunteers
- Yes
For 30 patients with documented Type 2 diabetes Inclusion Criteria: * Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures. * Age is \> or = 60 and \< or = 85 years of age * Documented Type 2 diabetes * Scoring 26 or higher on the MoCA test Exclusion criteria: * diagnosis of type 2 diabetes \< 1 year prior to enrollment * HbA1c \<6.5% or \>10.0% * body mass index \> 40 kg/m 2 * incident cardiovascular events in the last year (heart attack, stroke) * symptomatic coronary artery disease and…
Interventions
- OtherIntermittent Hypoxia 1 (IH1)
Intermittent Hypoxia 1 (IH1): 5 cycles of normoxia (4 minutes)/hypoxia (6 minutes) per session. 3 sessions per week for 8 weeks
- OtherIntermittent Hypoxia 2 (IH2)
Intermittent Hypoxia 1 (IH2): 5 cycles of normoxia (4 minutes)/hypoxia (6 minutes) per session. 3 sessions per week for 4 weeks
- OtherSHAM - normoxia
Participants will receive normoxia (no hypoxia) over 50 minutes.
Location
- University of IowaIowa City, Iowa