Cardiac Anodal Biphasic Pacing
Boston Medical Center
Summary
The goal of this study is to test a new pacing method called anodal biphasic pacing (ABP) to determine if this pacing works as well-or better-than current pacing methods. This new method may improve how the heart works and reduce some of the problems caused by regular pacing. Current implantable pacemakers use a monophasic cathodal waveform to stimulate the heart. Monophasic cathodal pacing (MCP) waveforms slow conduction, impair contractility, cause inflammation, increase risk of atrial fibrillation, heart failure, and mortality. Anodal biphasic pacing (ABP) is an alternative waveform that can stimulate the heart. ABP preconditions the heart and then initiates cardiac contraction. ABP may address the limitations of MCP.
Description
This study is a single-center, prospective, investigator-initiated, non-randomized, study that will investigate ABP in patients with structurally normal hearts and those with non-ischemic cardiomyopathy who are undergoing interventional cardiac procedure, generator exchange of dual chamber Cardiac implantable electronic device (CIED), or de novo implant or generator exchange of CIED with cardiac resynchronization therapy. Eligible participants, without heart disease and those with nonischemic cardiomyopathy, undergoing CIED implant or generator exchange or interventional cardiac procedure at…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Cohort A • Planned interventional cardiac procedure Cohort B * Planned generator exchange of dual chamber cardiac implantable electronic device (CIED) * Functioning atrial lead Cohort C * Planned de novo implant or generator exchange of CIED with cardiac resynchronization therapy * Functioning atrial lead Exclusion Criteria: * Permanent atrial fibrillation * Third degree AV block without stable escape rhythm * Ischemic heart disease or coronary disease \> 40% * Unable to receive heparin * Are not fluent in English * Unable to read in English * Not able to provide in…
Interventions
- DeviceCardiac Waveform Generator
A pacing device that allows for programmable pulse waveforms to generate a predefined set of anodal biphasic waveforms. It possesses a battery-powered floating point gate array (FPGA) using software that allows flexibility in waveform configuration.
Location
- Boston Medical CenterBoston, Massachusetts