Ketamine Use in Central Sensitization: a Study Evaluating the Use of Ketamine in Centrally Sensitized Endometriosis Patients
University Hospitals Cleveland Medical Center
Summary
The purpose of this research study is to see if ketamine infusion during surgery can decrease pain after surgery. Ketamine is a medication commonly used as part of anesthesia during surgery and is approved by the US FDA. Patients will be randomized to either receive standard anesthesia with OR without ketamine. The surgical procedure will be the same regardless of which group patients are randomized to. After surgery, patients will be asked to rate their pain in the post-operative observation unit and at their two-week post-operative visit. No additional visits are required for participation in this study. The investigators estimate the surveys will take approximately 10 minutes to complete.
Eligibility
- Age range
- 18–89 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * age range 18-89 * ASA classification I-III * outpatient elective laparoscopy for endometriosis Exclusion Criteria: * known allergy or contraindication to ketamine * History of substance use disorder, including alcohol or marijuana use, both current and remote * History of severe psychiatric illness, including schizoaffective disorder, bipolar disorder, psychosis, or decompensated psychiatric condition , excluding anxiety and depression * Current Intraoperative complications
Interventions
- Drugketamine
Participants will receive general anesthesia with protocoled ketamine infusion
Location
- University Hospitals Cleveland Medical CenterCleveland, Ohio