Feasibility Trial of Combination of Obstetrical Carrier Screening and Hereditary Cancer Screening
Columbia University
Summary
The investigators hypothesize that preconception and pregnancy may be a feasible and effective time to offer inherited cancer risk screening. This study will assess interest in cancer genetic testing among patients receiving routine prenatal care or preconception care. The goal is to evaluate the acceptability of hereditary cancer testing when offered alongside standard prenatal genetic screening. The study will also explore whether universal screening in this population could support early cancer prevention
Description
In this prospective trial, a clinician in the department of OBGYN will meet with preconception/pregnant patients who are undergoing obstetrical carrier screening (OCS) at Columbia University affiliated OBGYN clinics to review the options for concurrent hereditary cancer screening (HCS). If interested in the study, the patient will be contacted by a study coordinator and offered participation in the study. The patients will have counseling on potential risks and benefits of genetics testing and have OCS performed per standard of care protocols. This consultation will include collection of compr…
Eligibility
- Age range
- 18–55 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion criteria: * Age: 18 years - 55 years * Patients receiving obstetrical-related care at a CUMC-affiliated enrollment site * Patients who have elected to undergo OCS with the CUMC-affiliated obstetrics provider * Patients with prior OCS but planned to repeat OCS are eligible * Patients can speak and read in English or Spanish Exclusion criteria: * Patients who have previously completed a multigene hereditary cancer syndrome panel * Patients that have a hematologic cancer or hematologic pre-cancer * Patients who have a history of an autologous bone marrow transplant
Interventions
- DeviceNatera empower comprehensive hereditary cancer panel
Natera Empower Comprehensive Hereditary Cancer Panel to screen for hereditary cancers
- DeviceObstetrical carrier screening
Obstetrical carrier screening for genetic conditions
Location
- Columbia University Irving Medical CenterNew York, New York