Prospective Identification of Hypoxic Ischemic Brain Injury Using Portable Magnetic Resonance Imaging
Yale University
Summary
The goal of this study is to look for brain injury in patients who had a cardiac arrest, using portable brain imaging. The portable nature of this test will also allow for serial imaging so the investigators can understand how brain injury changes over days. The results of this study may allow for bedside imaging to be available at centers without specialized imaging centers and may identify markers of brain injury that help to select the patients most likely to benefit for clinical trials.
Description
Cardiac arrest occurs when the heart stops beating. This can occur for many reasons ranging from a heart attack to a drug overdose. It claims close to 500,000 lives a year. Even though the heartbeat is restored, blood flow to the brain remains below what is required for normal function. Brain injury is common in patients who had a cardiac arrest and few return to independence. Most patients are in a coma following cardiac arrest. Some patients wake up within the first days to week, but most do not. Physicians rely on tests, such as brain imaging, brain wave tests, and lab tests to help predict…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Unresponsive immediately after ROSC from IHCA or OHCA * Age ≥ 18 years of age * Conventional MRI is clinically indicated * Treatment with temperature control Exclusion Criteria: * MRI contraindication according to the American Heart Association guidelines * Inability to tolerate supine positioning for 30 minutes * Diffuse loss of grey-white differentiation and sulcal effacement on head computed tomography within 6 hours of ROSC
Interventions
- Deviceportable MRI scanner
Participants will receive 2-3 portable MRI scans: \<6 hours, 6-24 hours, and within 12 (+/- 12) hours of conventional MRI
Location
- Yale New Haven HospitalNew Haven, Connecticut