Time Restricted Eating (TRE) in Bipolar Disorder
Massachusetts General Hospital
Summary
This is a randomized controlled trial investigating the effects of an 8-TRE intervention compared to a wait list (control) on metabolic health and body composition in people diagnosed with BD and who are currently obese and at least mildly depressed. Following a 1-week baseline assessment, participants will be randomized to either a TRE or the wait list (1-to-1 ratio) for 8 weeks. At baseline, Week 8 (post treatment), and Week 20 (follow-up), investigators will assess daily eating patterns for one week, followed by collection of fasting lipids, body weight and vital signs. At Week 4 (i.e., mid-treatment), the investigators will assess self-reported outcomes only. Participants assigned to the wait list condition will have the option of receiving the TRE intervention after 20 weeks.
Description
The overall goal of this study is to examine the effects of TRE on weight loss and secondary health outcomes in individuals with BD,. A secondary goal is to determine whether these effects are mediated by improvements in circadian rhythms. Using an 8-week trial of 8-hour TRE compared to a wait list control group, the study will test the following specific aims: * Examine the effect TRE on weight loss * if compared to wait list control, individuals assigned to TRE will have greater improvement in waist circumference, depression, anxiety, cognition, sleep and daily functioning. * if a change i…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults (aged 18-65 years) * Diagnosed with bipolar disorder (i.e., subtype Bipolar I or II as assessed with the Quick SCID)21 * Currently experiencing depression (i.e., PHQ-9 ≥ 10)22 * Currently overweight (i.e., Body mass index (BMI) \> 30 kg/m2) * Provides Informed Consent Exclusion Criteria: 1. Dietary factors: 1. Diagnosis, or strong clinical suspicion, of eating disorders, including but not limited to, anorexia nervosa, bulimia nervosa, binge eating disorder (as assessed with the Quick SCID) 2. Concurrent dietary intervention or modification unrelated to st…
Interventions
- OtherTime Restricted Eating
See arms description
Location
- Massachusetts General HospitalBoston, Massachusetts