CHAMPION: Combining HIV And Meth Prevention and Treatment Interventions Optimized for HIV-Negative MSM
University of California, San Diego
Summary
The goal of this randomized controlled trial is to pilot test new mobile health (mHealth) interventions to improve PrEP adherence among HIV-negative men who have sex with men (MSM) with mild to moderate methamphetamine use disorder (MUD). The CHAMPION intervention combines two mHealth tools-PrEPAPP and CBT4CBT-to address both HIV prevention and MUD treatment needs in this population. The study's specific aims are: * To evaluate the feasibility and acceptability of the CHAMPION intervention based on treatment retention and engagement rates. * To examine the preliminary efficacy the CHAMPION intervention to improve PrEP adherence, as measured by dried blood spot (DBS) tests compared to the waitlist control group.
Description
The CHAMPION (Combining HIV And Meth Prevention and Treatment Interventions Optimized for HIV-Negative MSM) study, a randomized controlled trial that aims to pilot test state-of-the-art multi-modal pharmaco-behavioral interventions to increase PrEP adherence among HIV-negative MSM who use meth, versus a waitlist control. The study will enroll 100 HIV-negative MSM with mild or moderate meth use disorder (MUD) and sub-optimal PrEP adherence. The study will follow participants for 6 months. The intervention arm will receive the 6-month mHealth intervention package, CHAMPION, at baseline, while th…
Eligibility
- Age range
- 18–40 years
- Sex
- Male
- Healthy volunteers
- No
Inclusion Criteria: 1. HIV-negative 2. Cis-gender male 3. Age 18-40 years old 4. Mild or moderate MUD (by DSM-5 SCID criteria) 5. Anal intercourse with one or more male partners in the past 6 months 6. Started daily oral PrEP more than 30 days ago and self-reported not always taking PrEP as prescribed in the past 30 days (consistent with PrEP It! inclusion criteria) 7. Willingness to participate in an mHealth study with a 6-month follow-up 8. Residing in San Diego or San Francisco County Exclusion Criteria: 1. Residing outside of San Diego or San Francisco County 2. Any condition that, in t…
Interventions
- BehavioralCHAMPION Intervention
MHealth intervention to enhance PrEP adherence, combined with computer-administered cognitive behavioral therapy for a 6-month period for the intervention arm.
- BehavioralDelayed CHAMPION Package
Informational resources for first 3-months of study, followed by CHAMPION intervention for final 3-months.
Location
- Center on Substance Use and HealthSan Francisco, California