National Institute of Allergy and Infectious Diseases (NIAID)
Background: Influenza (flu) is a virus that can infect humans and animals. In humans, the flu can cause mild symptoms such as fever, cough, sore throat, runny nose, muscle aches, headaches, and fatigue. It can also cause sinus infections or pneumonia. Some flu strains, such as H5N1 and H7N9, which come from birds, can lead to more severe symptoms or death. Others, like H10N7, also come from birds but usually cause mild symptoms. Researchers want to study bird flu in humans to help develop new flu vaccines and treatments. Objective: To learn more about how bird flu viruses infect humans. Eligibility: Healthy people aged 18 to 55 years who were infected with the H10N7 bird flu strain as part of a previous study. Design: Participants who were infected with H10N7 in a previous study will be infected again with the same virus. The virus will be sprayed into their nostrils. Participants will stay in the hospital for at least 9 days. They will stay in an isolation unit. No outside visitors will be allowed. During their stay, participants will provide blood, urine, and nasal fluid samples. They will have tests of their heart and lung function. They will complete questionnaires about their symptoms. Participants will remain in the hospital until they test negative for the flu 2 days in a row. They will continue to complete questionnaires about their symptoms for 2 weeks after they were infected with the virus. Participants will have 2 follow-up visits, at 5 weeks and 9 weeks after they were infected. They will have a physical exam and provide samples of blood and nasal fluids. They will have a test of their heart function. ...
This is a single-center study to evaluate infection after a second exposure to a low pathogenicity avian influenza A H10N7. Participants who have previously been challenged with H10N7 willbe rechallenged with 10\^7 Tissue Culture Infective Dose (TCID50) virus and followed for a minimum of 9 weeks after inoculation. The study hypothesis is that mild to moderate influenza disease (MMID) can be induced with the A/Mallard/Ohio/99/1989 H10N7 influenza challenge virus on re-exposure despite the potential development of immunity after the last challenge. This will be evaluated by monitoring participa…
* INCLUSION CRITERIA: An individual must meet all of the following criteria to be eligible for study participation: 1. Previously participated in the H10N7 influenza challenge study 20-I-0160 ("Dose- Escalation Study of a Low Pathogenicity Avian H10N7 Influenza Virus in a Healthy Human Challenge Model") and given a viral challenge H10N7. 2. \>=18 and \<=55 years of age. 3. Able to provide informed consent. 4. Agrees to not use tobacco products, marijuana, or vaping products through the last mandatory visit. 5. Willing to remain in isolation for a minimum of 9 calendar days (or for the durati…
Low pathogenicity avian influenza virus H10N7