Fastomics: Metabolic and Therapeutic Effects of Prolonged Fasting
University of Minnesota
Summary
This is an observational study investigating how the metabolic and cell marker changes in Prolonged Fasting in the serum may be used against a cell-based model of disease for therapeutic purposes.
Description
There is potential benefit to prolonged water fasting, fasting with ad libitum water intake and consciously eating little to no food or caloric beverages, with regards to reducing weight, fat mass, insulin resistance and oxidative stress while improving glycemic control. Multiple studies have shown that prolonged water-only Fasting for 5-20 days has been safe in humans. A minimum of 2-3 liters of water intake daily is recommended by previous studies in which longer periods of up to 8 days fasting were observed. Prolonged fasting (36 hours) in humans upregulated multiple bioactive metabolites i…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Ages of 18-65 years old * Not pregnant * No comorbid conditions * BMI of 18.5-29.9. * Has a smartphone Exclusion Criteria: * Concern for active eating disorder per screening questionnaire * Self-reported eating disorder or history of eating disorder * History of hypoglycemia or contraindication for Prolonged Fasting * Weight \<120lbs * History of blood donation within the last 3 months.
Interventions
- OtherFasting
fast with water for up to 60 hours while wearing continuous glucose monitors
Location
- University of MinnesotaMinneapolis, Minnesota