Mayo Clinic
The purpose of this study is to investigate the use of ultra-low, anti-inflammatory doses of radiation therapy (RT) for the treatment of Parkinson's Disease (PD). In this study, the TrueBeam LINAC utilizes a linear accelerator (LINAC) for the delivery of radiation therapy. Dynamic conformal arc (DCA) therapy will be used to deliver a total of five (5) once-a-day radiation treatments (RT) using DaT-SPECT (Dopamine Transporter-Single-Photon Emission Computed Tomography) and MRI imaging to guide radiation treatment planning.
Inclusion Criteria * Age ≥ 45 and ≤ 70 years * Diagnosis of Parkinson's disease by a Movement Disorder Neurologist * Confirmation of unilateral Parkinson's disease by Dopamine Transporter (DaT) scan * A score of 2 or less on the modified Hoehn and Yahr scale * ECOG Performance Status (PS) ≤ 2 (Appendix I). * No known genetic causes or predisposition to Parkinson's disease or related diseases. * Ability to complete questionnaires, neurological exam, and follow-up imaging independently or with assistance * Ability to provide written informed consent * Willing to provide mandatory blood samples…
Dynamic conformal arc (DCA) therapy will be used to deliver a total of five (5) 60cGy once-a-day radiation treatments (RT) using DaT-SPECT (Dopamine Transporter-Single-Photon Emission Computed Tomography) and MRI imaging to guide radiation treatment planning.
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