University of Louisville
The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a control group of TKA patients receiving postoperative Oxycodone.
The purpose of this prospective, randomized study is to compare the outcomes of two cohorts of patients undergoing primary total knee arthroplasty (TKA) and to determine whether postoperative administration of oral dosage of suzetrigine is effective at reducing postoperative pain versus a control group of patients receiving oral dosage of oxycodone only following primary total knee arthroplasty. The primary objective will be to compare the amount of postoperative narcotics utilized and postoperative VAS pain levels. The secondary objective will be to compare variables of patient functionality…
Inclusion Criteria: 1. Patient age is 21-89 at time of surgery 2. Patient is scheduled to undergo a unilateral primary TKA, secondary to osteoarthritis 3. Patient agrees to participate as a study subject and signs the Informed Consent and Research Authorization document 4. Patient is able to read and speak English. Exclusion Criteria: 1. Patient is under the age of 21 2. Patient's primary diagnosis is not osteoarthritis 3. Patient is unable to read and speak English 4. Contraindication or Hypersensitivity to suzetrigine 5. Pregnant or nursing females 6. Patient has taken opioids within the…
patient receives a two-week supply of oral suzetrigine upon discharge
Patient will receive a two-week supply of oral Oxycodone upon discharge
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