Reactions to Learning Amyloid and Tau Results in Adults at Risk for Alzheimer's Dementia
University of Wisconsin, Madison
Summary
This is a prospective, single-cohort, single-center, observational study to assess if learning one's Alzheimer's disease biomarker test result impacts longitudinal psychosocial, behavioral, and neuropsychological outcomes, and to identify factors that moderate and mediate these outcomes. Participants enrolled in this study are requested to complete surveys at four timepoints after learning their Alzheimer's biomarker test results.
Description
The overall objective is to determine how learning one's amyloid and tau test results impacts longitudinal psychosocial, behavioral, and neuropsychological outcomes, and identify factors that moderate and mediate these outcomes. The rationale is that by understanding factors that explain variability in reactions, biomarker communication and post-testing support can be tailored to optimize outcomes. The central hypothesis is that learning biomarker profile will affect psychosocial, behavioral, and neuropsychological outcomes, and that these outcomes will be moderated by social determinants of…
Eligibility
- Age range
- 50–89 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Willing to provide informed consent. * Willing to comply with all study procedures and be available for the duration of the study. * Individuals at least 50 years of age. * Enrolled in Wisconsin Registry for Alzheimer's Prevention (WRAP) or Alzheimer's Disease Research Center Clinical Core (ADRC) * Previously adjudicated as cognitively unimpaired having mild cognitive impairment (MCI), or impaired but do not meet diagnostic criteria for mild cognitive impairment or dementia (classified as "Impaired-Not MCI" by the WRAP and ADRC cohorts) at their last WRAP or ADRC study v…
Interventions
- OtherDisclose amyloid, tau results
Release of results from investigational agents conducted under IND 107114, IND 166860, and IND 134516
- OtherFollow-up Assessments
self-report psychosocial and behavioral questionnaires
Location
- University of WisconsinMadison, Wisconsin