Gastrointestinal Response of Pediatric Cystic Fibrosis Patients on Mediterranean Diet
Dartmouth-Hitchcock Medical Center
Summary
There is no study to date that has evaluated the impact or effect of a Mediterranean diet in children with CF. The goal of this study would be to help provide better guidance around questions the investigators, as CF care providers continue to receive from patients and families about how to best promote overall health in pediatric cystic fibrosis from a dietary perspective. Currently, the updated nutritional recommendations are variable and broad. Parents continue to search for more concrete guidance about how best to promote long-term health given the ever-increasing life expectancy of cystic fibrosis patients in this new area of advanced therapeutics. Given the changing landscape of the CF care in general, children are less likely to struggle with early life malnutrition, and it is becoming increasingly clear that high fat, high calorie diets are not beneficial nor are necessary for all children with CF.
Description
The dietary needs of children with Cystic Fibrosis continue to change. With the advent of highly effective modulator therapy, these needs are profoundly shifting away from the standard advice of high calorie, high fat to varied, regular and moderated calorie. Obesity is a problem the investigators now confront with regularity and has prompted the need for more specific, dietary advice to parents who are eager to find sustainable meal plans that promote health overall. There is significant data to suggest that the Mediterranean Diet is the pinnacle of dietary health in everything from metaboli…
Eligibility
- Age range
- 3–18 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Male and female pediatric patient with cystic fibrosis age 3 and older * Nutritional status defined as a BMI Z-score of at least -1 or above * Confirm diagnosis of CF defined by 2 CF causing mutations on genetic testing or sweat chloride greater than 60 mEq/L * Children with pancreatic insufficient CF and on PERT * Children with pancreatic sufficient CF not on PERT * Child must be on a full, solids based diet * Family willing to child adhere to an exclusive Mediterranean style diet for a period of 6 months * Child must be able to follow-up at regular CF clinic visits and…
Interventions
- OtherMediterranean diet
Patients enrolled in this study will follow a Mediterranean diet for a 6 month period.
Locations (2)
- Dartmouth Hitchcock Medical CenterLebanon, New Hampshire
- Dartmouth Health Children'sManchester, New Hampshire