Human Hippocampal Oscillations During Visuomotor Exploration
NYU Langone Health
Summary
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
Description
Aim 1 - Visual Exploration in Surgical Patients Investigators will study 20 surgical patients with high-resolution intracranial EEG (iEEG) to investigate hippocampal activity during visual exploration. Participants will view between 10-15 panoramic environments using Meta Quest AR/VR glasses while their eye movements and head turns are tracked. Eye-tracking, head-turn, and iEEG data will be synchronized with visual stimuli, and intracranial EEG and single-unit data will be analyzed for changes in neuronal firing and brain activity before and after saccades. Aim 2 - Ambulatory Exploration in R…
Eligibility
- Age range
- 18–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: All subjects: * Adults (18-70 years) * Able to provide informed consent Aim 1: Surgical epilepsy patients' inclusion criteria * Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery * IQ=\>80\* Aim 2: RNS patients Inclusion criteria * Implanted RNS device with at least one hippocampal depth electrode * At least 5 months post-implantation to avoid the post-implant effect * Have a relatively low number of seizures, defined as =\<1 debilitating seizure per week * Able to walk and wear research equipment without assistance * IQ\>=80 Aim 2: Healthy Control I…
Interventions
- OtherVisual Exploration
Cognitive testing while admitted to the epilepsy monitoring unit (number of sessions will vary depending on patient availability and stamina).
- OtherAmbulatory Exploration
Series of cognitive tasks completed during a study visit.
Location
- NYU Langone HealthNew York, New York