Exercise and Mortality in Middle-Aged and Older Adults: A Target Trial Emulation
City of Hope Medical Center
Summary
This protocol is a retrospective study using the observational data of the the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial with over 150,000 participants aged 55-74 years to conduct a target trial emulation to examine the association between self-reported exercise and all cause and cause-specific mortality in apparently healthy, middle-aged and older adults. The PLCO includes assessments of participants' exercise level at two timepoints: at randomization into the PLCO trial (Q0) and 5-7 years after randomization into the PLCO (Q1).
Eligibility
- Age range
- 55–74 years
- Sex
- All
- Healthy volunteers
- No
* Adults enrolled into the PLCO screening trial. * Among participants reporting low exercise at Q0 (i.e., 0 or less than 1 day/week, with each session \<15 minutes in duration), completion of an exercise survey at Q1 as part of PLCO standard trial procedures no later than 5 years after reporting non-exercising status \[i.e., no exercise) at Q0. * No evidence of any of the following absolute contraindications to exercise: uncontrolled hypertension, symptomatic valvular disease; hypertrophic cardiomyopathy; unstable angina pectoris; primary pulmonary hypertension; heart failure; severe arrhythmi…
Interventions
- BehavioralControl
0 or less than 1 day per week, with each session, on average \< 15 minutes.
- BehavioralExercise
\>/= 2 days per week of moderate or vigorous intensity, with each session, on average, \>/=20 minutes in duration.
Location
- City of Hope Medical CenterDuarte, California