University of California, San Francisco
This study investigates the effects of brain radiotherapy on cognitive function by evaluating plasma biomarkers and apolipoprotein E (APOE) genotype in patients with primary or metastatic brain tumors. Standard brain radiotherapy is known to impact cognitive outcomes, yet the underlying biological mechanisms remain unclear.
PRIMARY OBJECTIVES: 1. Assess plasma biomarkers for Aβ, GFAP, phospho Tau, and NfL pre- and post-radiotherapy. 2. Determine APOE genotype. 3. Evaluate neuropsychiatric testing aligned with standard of care brain MRIs and serum markers. 4. Measure brain morphometrics pre- and post-radiotherapy with standard of care brain MRIs. SECONDARY OBJECTIVES: 1\. Measure patient-reported quality of life changes pre- and post-radiotherapy using a standard University of California, San Francisco (UCSF) -approved questionnaire. OUTLINE: This is a single-arm, non-randomized, open-label pilot study. Parti…
Inclusion Criteria: 1. \>= 18 years old 2. Diagnosis of a primary brain tumor OR #3. Not both #2 and #3. 3. Diagnosis of primary solid tumor and secondary involvement of the brain 4. If the patient has brain metastases: fewer than 5 brain metastases (post-operative and definitive allowed), none \> 1 cm in max diameter. 5. Candidate for standard of care / usual care (SOC) focused brain radiotherapy. 6. No prior brain radiotherapy, including whole brain radiotherapy. 7. Eastern Cooperative Oncology Group (ECOG) functional score 0 or 1. 8. Estimated life expectancy post-treatment of \> 2 years.…
Blood sample will be collected
Brain MRI will be performed during the course of data collection
Brain Health Assessment will be performed during the course of data collection
QoL questionnaire will be given to participants during the course of data collection
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