Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

Stanford University

Summary

The goal of the study is to examine how two key subregions of the human thalamus (ANT and PLV) are connected with other brain structures (Aim 1), how seizures involve the two thalamic subregions differently and how the map of cortico-thalamic ictal propagation matches the intrinsic connectivity maps identified in the same individuals (Aim 2), and the effect of ANT and PLV stimulations on memory formation (Aim 3).

Eligibility

Age range: 18–65 years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: * No medical or surgical contraindication to electrode implantation * Patient capable of understanding the scope of our project or signing informed consent independently Exclusion Criteria: * Unable to provide informed consent

Interventions

Other
Cognitive experiment
Record brain activity during memory encoding
Other
Electrical stimulation of the brain
Measure accuracy and reaction time during cognitive tasks

Location

Stanford Hospital
Stanford, California

Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation

Summary

Eligibility

Interventions

Location

Run this study?

Details

Conditions