Adjuvant STeRoid Outcomes in Idiopathic Subglottic Stenosis

Johns Hopkins University

Summary

This study will examine the ability of steroid injections into the site of stenosis following surgical dilation to delay the need for repeated surgical dilations.

Eligibility

Age range: 18–80 years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: * Have a life expectancy of ≥6 months; and, * Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1. Exclusion Criteria: * History of subglottic stenosis from identifiable cause (not idiopathic), including any of the below clinical criteria: * Prolonged endotracheal intubation or tracheostomy (intervention greater than 7 days immediately prior to diagnosis of subglottic stenosis); * External physical trauma (including but not limited to blunt, penetration, chemical, or thermal injury) that causes injury to the subglottis; * Clinical diagnosis of granuloma…

Interventions

Drug
Triamcinolone 0.1%
Intralesional Triamcinolone injection 3x at one, two, and three months following surgical dilation
Drug
Placebo
Intralesional Placebo injection 3x at one, two, and three months following surgical dilation

Location

Johns Hopkins Hospital
Baltimore, Maryland
scollin7@jh.edu 410-702-0421