Adjuvant Steroid Outcomes in Idiopathic Subglottic Stenosis

Johns Hopkins University

Summary

This study will examine the ability of steroid injections into the site of stenosis following surgical dilation to delay the need for repeated surgical dilations.

Eligibility

Age range: 18–80 years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: 1. Diagnosis of iSGS following the NoAAC criteria which involves ruling out known causes for airway stenosis. Participants may be newly diagnosed or carry an existing diagnosis of iSGS; 2. Age Range: 18 years to 80 years old at the time of consent; 3. Sex distribution: all eligible men and women will be included, and no one will be excluded; 4. Have a life expectancy of ≥6 months; and, 5. ECOG performance status of 0 or 1. Exclusion Criteria: 1. History of subglottic stenosis from identifiable cause (not idiopathic), including any of the below clinical criteria: 1. P…

Interventions

Drug
Triamcinolone 0.1%
Intralesional Triamcinolone injection 3x at one, two, and three months following surgical dilation
Drug
Placebo
Intralesional Placebo injection 3x at one, two, and three months following surgical dilation

Locations (10)

University of California - San Diego
San Diego, California
djcates@health.ucsd.edu
University of California - San Francisco
San Francisco, California
meera.kohli@ucsf.edu
University of Colorado
Aurora, Colorado
yosr.doghri@cuanschutz.edu
University of South Florida
Tampa, Florida
jdpersaud@usf.edu
University of Iowa Hospitals and Clinics
Iowa City, Iowa
emma-thayer@uiowa.edu
Johns Hopkins Hospital
Baltimore, Maryland
shirsh1@jh.edu 434-962-3058