Effects of Grape Consumption on Immune and Gut Health in the Setting of Obesity
University of Missouri-Columbia
Summary
This study is investigating the benefits of whole freeze-dried grape powder consumption on the immune-gut axis in adults with obesity.
Description
The study is a 12-wk randomized, controlled, crossover trial. Participants will be randomized to one of two intervention sequences, either consuming 48g/day of whole freeze-dried grape powder followed by an isocaloric placebo powder or consuming the placebo powder followed by the whole freeze-dried grape powder. Active intervention phases will be 4 weeks in duration followed by a 4-week washout period between treatments.
Eligibility
- Age range
- 30–45 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age: 30-45 years * Obesity with BMI of 30-45 kg/m2 * Willingness to consume study foods * Consistent diet and activity patterns for 4 weeks * Weight stable (\<5kg change over last 3 months) * Non-smoker \> 1 year or more * Not currently consuming an extremely healthy diet Exclusion Criteria: * Study food allergies * Regular consumption of grapes or grape-derived products * Gastrointestinal disease and/or bariatric surgery * Uncontrolled hypertension and blood pressure \>180/110 * Diabetes * Clinical Depression * Illicit drug use * History of alcohol or drug abuse * Rec…
Interventions
- OtherFreeze-dried grape powder
48 g/day oral consumption during the 4-week active period.
- OtherPlacebo powder
Isocaloric placebo matched to grape powder; oral consumption during the 4-week active period.
Location
- University of Missouri-ColumbiaColumbia, Missouri