Kinetic Analysis of Immune Cells in Blood and Chronic Graft-Versus-Host Disease-Affected Tissues After Allogeneic Hematopoietic Cell Transplantation
City of Hope Medical Center
Summary
This study evaluates the factors that contribute to chronic graft-versus-host disease, which is a complication that can occur after allogeneic hematopoietic cell transplantation.
Description
PRIMARY OBJECTIVE: I. Characterize immune cells and their subsets in peripheral blood of patients who develop and do not develop chronic graft-versus-host disease (cGVHD). OUTLINE: This is an observational study. Patients are assigned to 1 of 2 cohorts. COHORT 1: Patients undergo blood, saliva/buccal, and stool sample collection for up to 2 years on study. Patients also have their medical records reviewed on study. COHORT 2: Patients undergo a one-time blood, saliva/buccal, and stool sample collection and have their medical records reviewed on study.
Eligibility
- Age range
- 7+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * \* BOTH COHORTS: * Documented written informed consent of the participant and/or parent/guardian. * Assent from pediatric participants will be documented per institutional policies and practice. * Patients who have received allogeneic hematopoietic cell transplant (HCT) regardless of donor type, condition regimen, or GVHD prophylaxis. * Age: ≥ 18 years or ≥ 7 years if 30 kg and above * Willingness to: * Provide blood sample(s), stool, saliva, and buccal mucosa, * If applicable: Permit medical record/ clinical laboratory result review * COHOR…
Interventions
- OtherNon-Interventional Study
Non-interventional study
Location
- City of Hope Medical CenterDuarte, California