Mercy Bon Secours Saint Vincent Medical Center
The aim of the study is to identify which medication (haloperidol or olanzapine) is most effective in treating nausea and abdominal pain associated with cannabinoid hyperemesis using a 10-point visual analog scale with intervals of 0.5.
Subjects will be weighed, have blood drawn (\~20 mL, 5 teaspoons) and analyzed (CBC w/diff, CMP, lipase, quantitative hcG (if female)), urinalysis with microscopy if indicated, urine drug screen, and an ECG as part of standard routine care for such complaint in the emergency department. After consent is obtained, subjects will then be asked to rate their baseline nausea and abdominal pain on two separate 10-cm visual analog scales (VASs) \[0-10, 0.5 for minor symptoms, 10 for severe symptoms\]. The subjects will be pre-randomized with a computer program by an unaffiliated person to evenly dis…
Inclusion Criteria: * subjects must meet ONE of the below criteria AND are a near-daily to daily user of cannabis by inhalation for greater than or equal to 6 months. 1. Have documented previous diagnosis of cannabinoid hyperemesis, or 2. Report (or on chart review) greater than or equal to 3 episodes of emesis in a cyclic pattern separated by greater than 1 month during the preceding 2 years, or 3. The provider suspects cannabinoid hyperemesis as the primary or equally likely primary diagnosis. Exclusion Criteria: * Ineligible subjects include age less than 18 years, weight less tha…
olanzapine 10 mg IM
Haloperidol 5 mg IM
Arctuva estimate
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