State-dependent Entrainment of Intrinsic Brain Rhythms to Improve Interregional Functional Coupling.
Medical University of South Carolina
Summary
This pilot study aims at establishing personalized state-based rTMS for precision neurorehabilitation, we designed a within-subject cross-over study to test closed-loop repetitive transcranial magnetic stimulation and electroencephalography (rTMS-EEG) comparing the targeting of two key nodes in the frontoparietal network during bimanual visuomotor force tracking in persons with upper extremity sensorimotor impairment affecting eye-hand control.
Description
There is a need for oscillatory or repetitive neuromodulatory tools and methods that are effective in entraining intrinsic neural rhythms to improve inefficient functional coupling within neural circuits. The goal of the proposed study is to develop a closed-loop application of repetitive transcranial magnetic stimulation (rTMS) and electroencephalography (EEG) suitable for use in multidomain precision neural-circuit based rehabilitation studies that permits the time-locked application of rTMS pulses to the phase of the intrinsic neural oscillation (personalized state-based application) in a d…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * adult volunteers (age ≥18 years) * right-hand dominance (defined with the Edinburg Handedness Scale) * voluntary whole-hand grip force (Medical Research Council scale for muscle force ≥2) * capable of repeated grasp and release with 5% of maximum voluntary contraction (standardized with an in-house computer-based assessment involving whole-hand grip force tracking upon visual cues with a digital dynamometer). Exclusion Criteria: * presence of any MRI risk factors (such as an electrically, magnetically, mechanically activated metal or nonmetal implant including cardiac…
Interventions
- Devicerepetitive transcranial magnetic stimulation (rTMS)
rTMS will be applied time-locked to the intrinsic brain rhythms to individually-defined brain regions
Location
- Medical University of South CarolinaCharleston, South Carolina