Memorial Sloan Kettering Cancer Center
The researchers are doing this study to evaluate the use of circulating tumor DNA (ctDNA) testing in making treatment decisions for advanced/recurrent endometrial cancer that has a change (mutation) in the mismatch repair deficient (MMR-D) gene or microsatellite instability high (MSI-H) gene. The researchers will see how doctors and their patients use the results of ctDNA testing after 1 year of standard chemotherapy and immune checkpoint inhibitor (ICI) treatment to decide whether to continue maintenance ICI treatment past 1 year. The researchers will also look at the health outcomes of people in this study (for example, whether they are cancer free at the end of their participation in the study).
Inclusion Criteria: * Patients must have pathologically confirmed endometrial cancer * Patients with advanced endometrial cancer * Stage III with residual disease °Select patients with Stage III disease and no residual disease can be enrolled after discussion with PI * Stage IV * Recurrent endometrial cancer after adjuvant therapy only * Patients can have primary or planned interval surgery * MMR-D on immunohistochemistry OR MSI-H using any commercially available test * Patients with treated brain metastases are eligible if follow up brain imaging after CNS directed therapy shows no eviden…
Patients will undergo ctDNA sampling at the 1-year timepoint using the commercially available Natera SignateraTM test.
at the 1-year timepoint
Patients and providers will also complete surveys at various timepoints to evaluate distress, shared decision-making, acceptability and other factors contributing to the decision-making process.
Will be performed within 6 months of receiving the 1-year clinical ctDNA result. Discussion via telephone or during a standard of care clinical visit (in person or telemedicine) with treating physician or team member within 28 days of clinical 1-year ctDNA result to discuss results with the patient and decide on de-escalation if applicable.