Motivated Decision-Making and Performance
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Summary
This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age 18 to 75 years old. * Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This symptom checklist provides a score based on the number and severity of symptoms. An individual with a score \>12 is classified as having PASC. * Currently experiencing Fatigue/Brain Fog as assessed with the Post-COVID symptom checklist and the PedsQL questionnaire. Exclusion Criteria: * Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizure…
Interventions
- BehavioralPhysical Fatigue
Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.
Location
- Kennedy Krieger InstituteBaltimore, Maryland