Pathophysiological Mechanisms of Cannabidiol in Stress Regulation

Summary

Dysregulation in stress responsivity is a growing psychiatry-transdiagnostic fundamental phenomenon, with limited therapeutic strategies. With the legalization of medical and recreational cannabis, many people consume cannabidiol (CBD; a nonintoxicating cannabinoid) to alleviate stress response, without the benefit of scientific guidance. To address this gap, the investigators propose a rigorous translational neuroscience study in a clinical high-risk population to define the roles of CBD in stress response with mechanisms of mesocorticolimbic-network function and hierarchy, neurometabolic, endocrine, and behavior, building upon convergent evidence from animal models and human evidence from our laboratories.

Description

Eligibility

Age range

18–25 years

Sex

All

Healthy volunteers

Yes

Interventions

• Drug
  Cannabidiol

  400mg cannabidiol

• Drug
  Placebo

  Inactive oral solution

Location