Mechanistic Randomized Controlled Feasibility Trial of Aspirin on Endometrium and Inflammatory Metabolites in Postmenopausal Women With Non-Atrophic Endometrial Changes

Summary

This phase IV trial studies whether low dose aspirin can be used to lower inflammation and prevent endometrial cancer in postmenopausal women with changes in the endometrial tissue that are not related to thinning (non-atrophic endometrial changes) and pain. As people age, there is an accumulation of fats, cell death, and inflammation, which causes a surge of pro-cancer-causing events. It is thought that there are several factors involved in the development of endometrial cancer, but that managing the inflammation may address the root cause. Low dose aspirin is aspirin that contains a lower dose than a standard adult tablet. Aspirin is a drug that reduces pain, fever, inflammation, and blood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention. Giving low dose aspirin may be an effective way to lower inflammation and prevent endometrial cancer in postmenopausal women with non-atrophic endometrial changes and pain.

Eligibility

Age range

Not specified

Sex

Female

Healthy volunteers

Yes

Interventions

• Procedure
  Biospecimen Collection

  Undergo blood, urine, and endometrial tissue sample collection

• Drug
  Low-Dose Aspirin

  Given PO

• Other
  Patient Observation

  Undergo observation

• Other
  Questionnaire Administration

  Ancillary studies

• Procedure
  Ultrasound Imaging

  Undergo pelvic ultrasound

Location