The Role of Diet and Gastrointestinal Motility in Irritable Bowel Syndrome (IBS)
Children's Hospital of Philadelphia
Summary
The goal of this observational study is to identify factors that influence symptoms in children with irritable bowel syndrome (IBS), to find ways to make diet treatments work better and possibly create personalized plans to help each child with IBS feel better. The main question it aims to answer is: 1. What types of food do the kids eat and how do these diets relate to their symptoms? 2. Is there any motility pattern that we can identify from the kids with or without IBS using a wearable patch? 3. What kinds of bacteria and chemicals are found in the gut and urine of children with IBS, and how are these linked to their IBS symptoms? Participants will use the wearable patch, answer questionnaires, collect stool and urine samples, and recall their 24 hours dietary.
Eligibility
- Age range
- 8–18 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Cases: 1. Males and females age 8 - 18 years 2. Diagnosis of irritable bowel syndrome (IBS). 3. Parental/guardian permission (informed consent) and child assent Controls: 1. Males and Females age 8-18 years 2. No diagnosis of abdominal pain disorder 3. Parental/guardian permission (informed consent) and child assent Exclusion Criteria: Cases: 1. Allergy to adhesives 2. Inability to cooperate with study design 3. Antibiotic intake in the past 4 weeks 4. Inflammatory gastrointestinal disorder diagnosis Controls: 1. Allergy to adhesives 2. Inability to cooperate with…
Interventions
- Diagnostic TestWireless Patch System
The Wireless Patch System will be placed on the abdominal skin. Participants will receive an iPhone containing the WPS app to record symptoms and meals. Participants undergoing a clinically indicated dietary intervention will complete study procedures before and after the dietary intervention.
Location
- Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania