An Open-Label Study On The Effects Of Human Secretin For Injection (CHIROSTIM) On Pancreatic Fluid Composition In Normal Human Volunteer Participants
Mayo Clinic
Summary
The purpose of this study is to collect pancreas fluid from the duodenum using the endoscopic pancreas function collection method in healthy participants after pancreatic stimulation with human secretin.
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria * Males or non-pregnant females * Age 18-80. * Participants must be in good health based on medical history (ASA Class 3 or below) * Participants must be willing and able to provide informed consent * Receiving an endoscopic ultrasound for a non-pancreatic indication Exclusion Criteria * History of any form of pancreatitis and/or other pancreatic diseases (e.g. pancreatic cysts, pancreatic masses). * History of inflammatory bowel disease * History of vagotomy. * History of surgically altered upper gastrointestinal anatomy (e.g. gastric bypass, Billroth I/II) * History of…
Interventions
- DrugSecretin (human synthetic) - ChiRhoClin
During endoscopic ultrasound (EUS), a dose of intravenous secretin (0.2 µg/kg) will be administered over the course of 1 minute to stimulate pancreatic ductal cells to secrete pancreas fluid. Duodenal fluid will be aspirated through the echoendoscope in 5 minute increments (5, 10, 15, and 20 minutes) after the secretin has been administered
Location
- Mayo Clinic in RochesterRochester, Minnesota