Neuroimaging of Sedation With Remimazolam
Keith M Vogt
Summary
This is a single-arm functional MRI study that will determine the effects of remimazolam on cognition and brain activity and connectivity at rest, during noxious stimulation, and during a memory encoding task
Eligibility
- Age range
- 18–59 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Adults 18-59 years of age, who: * have none of the specific exclusion criteria * have a valid email address and valid phone number throughout the study * free from any non-MRI compatible implants Exclusion Criteria: * are pregnant or attempting to conceive * body mass index (BMI) \> 35 * significant memory impairment or hearing loss * sleep apnea * chronic pain or frequently taking pain medication (including tramadol) * chronic medical conditions requiring treatment (hypertension, diabetes, high cholesterol) * neurologic disease, including seizures and tremor * psychia…
Interventions
- DrugRemimazolam
Subjects in this group will receive an intravenous infusion of this drug, during a portion of the study.
- DevicePeripheral Nerve Stimulation
Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with a fixed number of the experimental cues, in a pattern that appears random to participants.
Location
- University of PittsburghPittsburgh, Pennsylvania