Ketamine and Propofol NeuroImaging
Keith M Vogt
Summary
This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the commonly-used anesthetic agents ketamine and propofol, both alone and in combination.
Description
There are four independent drug-administration sessions, visits 1, 3, 5, and 7. In all four of these sessions, both drugs are received, but in two different sequences. Two of these are EEG sessions and two are MRI sessions. Both EEG and MRI will have the same two drug orderings: * Propofol alone, followed by ketamine and propofol together * Ketamine alone, followed by propofol and ketamine together Assignment to propofol alone first, versus ketamine alone first will be randomized. But, all subjects will be assigned to receive both drug orderings under both EEG monitoring and MRI acquisition.…
Eligibility
- Age range
- 18–59 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Adults 18-59 years of age, who: * have none of the specific exclusion criteria * have a valid email address and valid phone number throughout the study * free from any non-MRI compatible implants Exclusion Criteria: * are pregnant or attempting to conceive * body mass index (BMI) \> 35 * significant memory impairment or hearing loss * sleep apnea * chronic pain or frequently taking pain medication * chronic medical conditions requiring treatment (hypertension, diabetes, high cholesterol) * neurologic disease, including seizures and tremor * psychiatric diagnoses, inclu…
Interventions
- DrugPropofol
Subjects will receive an intravenous infusion of this drug, during portions of the study.
- DrugKetamine
Subjects will receive an intravenous infusion of this drug, during portions of the study.
- DevicePeripheral Nerve Stimulation
Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with specific experimental events.
Location
- University of PittsburghPittsburgh, Pennsylvania