Prospective Cross-Over Study of the Effects of Meal Macronutrients on Postprandial Lipids
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Summary
Background: Abnormal fats in the blood can lead to many problems, including heart disease. Researchers want to learn more about how eating meals with different levels of nutrients affects fats in the blood. Specifically, they want to study people with too much body fat, too little body fat, and a kidney problem called nephrotic syndrome. Objective: To learn more about how different types of foods affect fat levels in the blood. Eligibility: People aged 18 years or older with a health condition that affects how their body handles fats. Healthy volunteers are also needed. Design: Participants will have 2 overnight stays in the clinic within 6 months. At each visit, after staying overnight, they will eat a breakfast casserole. At 1 visit, breakfast will be a high-fat, low carbohydrate meal. At the other, it will be a high-carbohydrate, low-fat meal. Participants will have a tube inserted into a vein in their arm. They will have blood drawn via the tube 12 times in 8 hours: 2 times before they eat the breakfast and 10 times after. Participants will have other tests during their stays: * A resting metabolic test captures the air they exhale and measures how much energy they use at rest. * A dual energy X-ray absorptiometry (DXA) scan measures how much fat and muscle they have. * A Fibroscan is a special type of ultrasound of the liver. * A body surface scan uses lasers to measure the total area of the body. * A bioelectric impedance (BIS) exam measures how fast small electric currents move through their body. Participants may opt to have a third visit. At this visit, the breakfast will be high in protein....
Description
Study Description: This is a single site, randomized cross-over study assessing the effects of different test meals of varying macronutrient composition on post-prandial lipid metabolism. Studies will be conducted in healthy individuals and in several patient populations including those with nephrotic syndrome (NS), lipodystrophy, and metabolic syndrome. The study hypothesis is that the number, composition and kinetics of lipid-containing particles will differ in the post-prandial state: 1. Within subjects, comparing meals of differing macronutrient composition (i.e. high fat versus high ca…
Eligibility
- Age range
- 18–120 years
- Sex
- All
- Healthy volunteers
- No
* INCLUSION CRITERIA: Common inclusion criteria (all groups): In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Age \>= 18 years 2. Average alcohol intake in the past 6 months \< 3 drinks (approximately 30g) per day (male) or \< 2 drinks (approximately 20 g) per day (female) Healthy control specific inclusion criteria: 1. In good general health with no known active medical conditions as evidenced by medical history 2. Fasting glucose \<100 mg/dL 3. HbA1c \<5.7% 4. Fasting triglycerides \<150 mg/dL 5. ALT and AST within normal l…
Interventions
- OtherHigh carb then high fat breakfast
High carb then high fat breakfast
- OtherHigh fat then high carb breakfast
High fat then high carb breakfast
Location
- National Institutes of Health Clinical CenterBethesda, Maryland