The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study
Brigham and Women's Hospital
Summary
Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.
Description
The objective of this study is to test the utility of high sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) in risk stratifying patients with rheumatoid arthritis (RA) who may benefit from lipid lowering therapy. The population of interest are individuals who would not otherwise be recommended for therapy based on general population risk calculators for heart disease risk.
Eligibility
- Age range
- 35–79 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * RA diagnosed by a rheumatologist * Age 40- 79 * ≥1 ASCVD risk factor including prediabetes, hypertension, BMI \>30, current or history of cigarette smoking Exclusion Criteria: * Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor * Patients with diabetes mellitus * Pregnancy
Interventions
- Diagnostic Testhigh sensitivity cardiac troponin
Blood measurement of high sensitivity cardiac troponin
Location
- Brigham and Womens HospitalBoston, Massachusetts